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Identifying binding motifs or critical sequence segments is a key step toward understanding the mechanism of interactions between hepatitis C virus (HCV) and host cell proteins, such as human proteins. In the present study, we found a pair of binding motifs, G185-L234 in HCV NS5A proteins and L-X(3,5)-E-[AEGNQST] in human proteins, which are considered to be a key determinant for the interactions...
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