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We designed and prepared the new C 60 fullerene hybrids bearing a xanthine moiety as potential double-action anti-inflammatory agents, capable of simultaneous inhibition of LPS-induced NO and TNF-α production. The 10μM of fulleropyrrolidine-xanthine dyad 2a and b were effective in suppressing LPS-induced NO production by 55.1±2.1% and 58.6±2.6%, respectively, but only 2b was also effectively...
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