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One of the etiological theories of schizophrenia is dysregulation of the immune system. Autoantibodies specific for the α7 subunit of the nicotinic receptor could potentially contribute to the pathophysiology of the disease. In this study, positive antibodies specific for the receptor were found to exist in 23% of the patients diagnosed with schizophrenia (n=21). On the average, levels for the antibody...
A number of epidemiological studies have evaluated obstetric complications (OC) (McNeil, 1987, Lewis et al., 1989) and lower premorbid cognitive functioning (Rifkin et al., 1994) as important factors, which could lead to a neurodevelopmental defect and could increase the vulnerability to schizophrenia (Lewis & Murray, 1989, Zubin 1986).36 same-sex pairs of patients (schizophrenics, schizoaffectives)...
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