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Prostaglandin E 2 (PGE 2 ) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE 2 and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the healing of drill-hole injury in the femoral diaphysis. After...
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