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An asymmetric reaction can be implemented and refined in the helical cavity of aromatic oligoamide sequences. These sequences, which bear a chiral inducer, can fold into helical structures with absolute control of the helical sense, whereby a ketone substrate covalently linked in the cavity can be asymmetrically reduced to diastereomers. The diastereoselectivity of the reduction is highly dependent...
A series of folded aromatic oligoamides with absolute control of helical sense has been synthesized. These helices can implement an asymmetric reduction reaction in their cavities, and the diastereoselectivity of the reaction is significantly improved by optimization of the oligoamide sequences. More information can be found in the Research Article by Q. Gan and co‐workers (DOI: 10.1002/chem.202200834)...