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Chemotherapy for brain glioma has been of limited benefit due to the inability of drugs to penetrate the blood–brain barrier (BBB) and non-selective drug accumulation in the entire brain. To obviate these limitations, dual-targeting paclitaxel-loaded nanoparticles were developed by decoration with peptide-22 (PNP–PTX), a peptide with special affinity for low-density lipoprotein receptor (LDLR), to...
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