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Aspartic protease (PR) of HIV-1 virus represents a valid therapeutic target for the design of antiviral agents suitable for treatment of AIDS. We have designed peptidomimetic PR inhibitors containing a novel dihydroxyethylenediamine –Phe-Ψ[CHOH–CHOH]-Pro– core using molecular modelling approach that predicts the inhibitory potencies (IC50pre) in terms of computed relative enzyme–inhibitor complexation...
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