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Objectives
In mood disorders, chronic stimulation with stress results in aberrant regulation of the hypothalamic–pituitary–adrenal (HPA) axis. Lithium was shown to influence HPA axis function. The underlying genetic background as well as environmental context may influence the stress response, and therefore lithium efficacy. The aim of the present study was to analyze if genetic variants located...
Altered activity of hypothalamus–pituitary–adrenal glands (HPA) axis in response to stress underlies the pathogenesis of mood disorders such as depression and bipolar disorder. Chaperone proteins regulate sensitivity of glucocorticoid receptor (GR) to steroids. We hypothesized that genetic variants within the FKBP5 – gene encoding co-chaperone protein essential in GR signaling – may influence the...
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