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To explore the better prodrug of 4-aminosalicylic acid (4-ASA) with higher activity and less side effects against the inflammatory bowel disease. 4-ASA, after a succession of synthesis process, was conjugated with various carrier molecules to get seven azo derivatives of 4-ASA. All compounds were characterized by FT-IR, 1 H NMR, 13 C NMR spectras in detail. New derivatives of 4-ASA...
For searching a better 4-aminosalicylic acid derivative with higher activity and less side effects against the inflammatory bowel disease, 4-aminosalicylic acid (4-ASA) was protected by benzyloxycarbonyl and acetyl, respectively. The resultant was hydrogenized to remove protective group of amino group, then the product was reacted with NaNO 2 to give diazonium salt, which was conjugated with...
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