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AbstractTo compare the thrombolytic activity of YM866, a modified tissue-type plasminogen activator (t-PA), with that of alteplase in dogs with induced coronary artery thrombi and rats with induced carotid artery thrombi.Although t-PA remains effective in many patients, exhibiting a coronary reperfusion rate of ⩾70%, its high dosing regimen increases the possibility of systemic bleeding and acute...
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