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Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin’s lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3+CD4+ regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator of CRAC (calcium release activated calcium) channel, in SJL mice results in an accelerated...
Effector/memory T cells (Tem) are required to maintain successful immunity, while regulatory T cells (Treg) are required to prevent excessive/uncontrolled inflammation and/or autoimmunity. Although both Tem and Treg cells are increased during aging, the relationship between the increased proportion of Foxp3 + Treg cells and CD44 + Tem cells with aging is not clearly understood. We...
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