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The purinergic receptor P2X 7 is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X 7 receptors in vivo are non-selective cation channels or form large pores that can mediate apoptotic cell death. Expression of P2X 7 R in Xenopus oocytes results exclusively in formation of a non-selective...
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