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Tacrine enhanced acetylcholine-induced catecholamine secretion with a concentration of up to 10 μM, but inhibited it at over 10 μM in perfused adrenal glands. Qualitatively the same result was obtaiend withphysostigmine. Both tacrine and physostigmine only inhibited the secretory responses to carbachol and/or nicotine in perfused glands and dispersed chromaffin cells. Acetylcholinesterase activity...
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