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K + channels composed of GIRK subunits are predominantly expressed in the heart and various regions of the brain. They are activated by βγ-subunits released from pertussis toxin-sensitive G-proteins coupled to different seven-helix receptors. In rat atrial myocytes, activation of K (ACh) channels is strictly limited to receptors coupled to pertussis toxin-sensitive...
Muscarinic K + channels (I K(ACh) ) in native atrial myocytes are activated by βγ subunits of pertussis toxin (Ptx)-sensitive heterotrimeric G proteins coupled to different receptors. βγ subunits of Ptx-insensitive G s , coupled to β-adrenergic receptors, do not activate native I K(ACh) . In atrial myocytes from adult...
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