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Cerebral dopamine neurotrophic factor (CDNF) is a novel evolutionary conserved neurotrophic factor (NTF) which can protect and repairs dopamine neurons in animal models of Parkinson's disease. The crystal structure of CDNF is dominated by eight α-helices and the 3-dimensional structure of CDNF consists of an N-terminal saposin-like domain and a C-terminal SAP-domain. In particular, the C-terminal...
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