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To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study.ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years]...
The objective of this study was to consider whether trabecular bone score (TBS) improves on areal bone mineral density (aBMD) measurement alone for the prediction of incident fractures in postmenopausal women.The OPUS study was conducted in ambulatory European women aged above 55years, recruited in 5 centers followed over 6years. For the assessment of the performance of TBS, baseline Hologic scans...
The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone mineral density (BMD), osteoporotic fractures and polymorphisms of TGFB1, although these studies have yielded conflicting results.We investigated associations between TGFB1 polymorphisms and BMD and fracture in the GENOMOS...
Intravenous (IV) bisphosphonate dosing for women with postmenopausal osteoporosis is an attractive treatment option where oral therapy is inappropriate because of tolerability or compliance issues. Ibandronate, a potent nitrogen-containing bisphosphonate, can be administered by simple IV injection. The optimal dose and interval for this new regimen have been investigated in a detailed clinical trial...
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