The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Canonical type I interferon (IFN-I) signaling through interferon stimulated gene factor (ISGF) 3 has a key role in host innate and adaptive immune responses during viral infection. We have previously found that following systemic infection with lymphocytic choriomeningitis virus (LCMV), STAT1 KO but not WT, IFNAR KO or STAT1/IFNAR DKO mice develop lethal disease characterized by a ‘cytokine storm’...
STAT1 KO but not WT, STAT2 KO, IRF9 KO or IFNAR KO mice succumb to a lethal CD4+ T cell-mediated disease following systemic infection with lymphocytic choriomeningitis virus (LCMV). In previous studies we showed: (i) LCMV infection induces IRF7 gene expression in a STAT1-independent, but STAT2-dependent manner, and (2) IRF7 is required for IFN-alpha but not IFN-βετα production in LCMV infection. Here...
Interleukin (IL-) 6 plays a key role in the host response to injury and infection in the central nervous system (CNS). We identified strawberry notch 2 (Sbno2) as an IL-6/gp130 cytokine-signalling target gene in murine astrocytes and microglia. Sbno2 is a mouse homologue of the Sno gene in Drosophila to shown modulate Notch signalling. However, the function of Sbno2 in mammals is not known. Here,...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.