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Transmucosal delivery of therapeutic agents is a non-invasive approach that utilizes human entry paths such as the nasal, buccal, rectal and vaginal routes. Mucoadhesive polymers have the ability to adhere to the mucus layer covering those surfaces and by that promote drug release, targeting and absorption. We have recently demonstrated that acrylated polymers display enhanced mucoadhesive properties...
We have synthesized a novel mucoadhesive polymer, alginate–polyethylenglycol acrylate (alginate–PEGAc), in which an alginate backbone carries acrylated polyethylenglycol. This polymer combines the strength, simplicity and gelation ability of alginate with the mucoadhesion properties arising from the characteristics and acrylate functionality of PEG. The strong bonding to the mucus results from a combination...
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