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Monoclonal antibody G250 (mAb G250) recognizes a determinant on carbonic anhydrase IX (G250/CAIX). CAIX is expressed by virtually all renal cell carcinomas of the clear cell type (ccRCC). This can be explained by a direct molecular link between CAIX gene expression and (one of the) the initiating mutational event(s) in ccRCC: inactivation of the von Hippel—Lindau gene product. The combination of restricted...
Background CT imaging is widely used for response evaluation of immunotherapy in patients with advanced stage renal cell carcinoma (RCC). However, this kind of treatment may not immediately be cytoreductive, although the treatment is successful. This poses new demands on imaging modalities. Positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) proved to be useful in monitoring the...
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