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Recent reports have described the presence of cannabinoid CB 1 receptors in pancreatic islets. Here we show that administration of the endogenous cannabinoid anandamide or the selective cannabinoid CB 1 receptor agonist Arachidonyl-2′-chloroethylamide (ACEA) results in glucose intolerance after a glucose load. This effect is reversed by the selective cannabinoid CB 1 receptor...
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