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The paper contributes to the discussion on the usefulness of meta-analysis as compared to large scale trial. After reviewing the issues to consider when comparing the results of a meta-analysis and of a large trial, several examples, in particular in thoracic oncology, of complementary uses of meta-analysis and large trials are discussed. Three types of examples are presented: (a) trial designed to...
Despite the clinical efficacy of recombinant human erythropoietin (RHE) on chemotherapy-induced anemia, most cost-effectiveness studies have given unfavorable results.To determine the cost of managing anemia in unselected patients receiving chemotherapy for lung cancer, and the efficacy and cost-effectiveness of RHE.We constructed Markov models of two cohorts of patients who received (n=94) or did...
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