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Nanomedicine
In article number 2210047, Vojtech Adam, Nan Li, and co‐workers construct a Zr‐based metal–organic framework with a Cu‐based probe via a microfluidic approach to downregulate inflamed intestinal H2S levels, thus restoring the intestinal lumen milieu. This research offers the motivation for the further exploration of nanomedicines to treat other intestinal diseases.
Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption, and tight junction (TJ) proteins loss. Excess of H2S in the intestinal milieu produced by the sulfate‐reducing bacteria metabolism contributes to development of IBDs via epithelial barrier breakdown. Conventional interventions, such...