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The peptide sequence YMESRADRKLAEVGRVYLFL, derived from 313-332 region of the αIIb, has been identified as a potent inhibitor of platelet aggregation and fibrinogen binding to αIIbβ3. More detailed studies have revealed that the Y313MESRADR320 sequence is the shortest octapeptide with strong inhibitory activity. This work provides insight of the solution conformation of these peptides, by performing...
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