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Deletion of connexin (Cx) 43 from osteoblasts and osteocytes (OCN-Cre;Cx43fl/− mice) or from osteocytes only (DMP1-8kb-Cre;Cx43fl/fl mice) results in increased cortical, but not cancellous, osteocyte apoptosis and widening of the femoral midshaft without changes in cortical thickness. Despite the consequent larger moment of inertia, stiffness and ultimate load, measures of mechanical strength assessed...
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