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Clopidogrel treatment in patients with coronary artery disease not only inhibits platelet activation but also improves endothelial function and nitric oxide (NO) bioavailability. Congestive heart failure (CHF) is associated with endothelial dysfunction and increased platelet activation. In rats with CHF following myocardial infarction (MI), we investigated whether treatment with clopidogrel modifies...
Orale Thrombozyteninhibitoren, insbesondere Acetylsalicylsäure (ASS) und die Gruppe der Thienopyridine (Clopidogrel), sind Grundpfeiler in der Therapie kardiovaskulärer Erkrankungen. Dies unterstreicht die wichtige pathophysiologische Rolle der Thrombozytenaktivierung in der Progression von Atherosklerose und akuten klinischen Ereignissen wie Myokardinfarkt und Schlaganfall. Unvollständige Hemmung...
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