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U chorych na nowotwory, ból o umiarkowanym i silnym natężeniu wymaga stosowania analgetyków opioidowych. Choć opioidy cechuje zwykle wysoka skuteczność analgetyczna, leki te wywołują także liczne działania niepożądane, zwłaszcza ze strony przewodu pokarmowego, określane mianem poopioidowych zaburzeń czynności jelit (opioid-induced bowel dysfunction). W ostatnich latach podjęto próby leczenia przyczynowego...
Background To assess methadone analgesia, adverse effects, and calculation method of equianalgesic doses with oral morphine. Materials and methods Methadone was administered to 21 opioid-tolerant cancer patients because of pain (numerical rating scale [NRS] > 5) on morphine (ten patients), transdermal fentanyl (TF; four patients), morphine, ketamine, and TF (one patient), tramadol (one patient),...
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