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The technical limitations of isolating target cells have restricted the utility of pluripotent embryonic stem (ES) cells. For example, early cardiac (i.e., precontractile) cells have not been isolated from ES cells. Here, we find that direct expression of reporter genes under cell-specific promoters—the currently available strategy for isolating cells lacking cell-specific surface markers—is ineffective...
It is unknown whether heparin-binding EGF-like growth factor (HB-EGF) can be a therapeutic agent, although previous studies suggested that HB-EGF might be a hepatotrophic factor. This study explores the potential of hepatic HB-EGF gene therapy in comparison with HGF.Mice received an intraperitoneal injection of the agonistic anti-Fas antibody 72h after an intravenous injection of either adenoviral...
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