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We investigated how virgin olive oil (VOO) affected platelet and hypoxic brain damage in rats. Rats were given VOO orally for 30 days at 0.25 or 0.5 mL kg−1 per day (doses A and B, respectively). Platelet aggregation, thromboxane B2, 6-keto-PGF1α, and nitrites + nitrates were measured, and hypoxic damage was evaluated in a hypoxia–reoxygenation assay with fresh brain slices. Oxidative stress, prostaglandin...
Triflusal is a fluorinated derivative of acetylsalicylic acid (ASA) with demonstrated antithrombotic activity. Recently, evidence for a neuroprotective effect has been obtained. The aim of this study was to compare the neuroprotective effects of the main metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid, HTB) and the ASA metabolite salicylic acid (SA) in an in vitro model of anoxia-reoxygenation...
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