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The resistance of mycobacteria to β-lactam antibiotics is attributed to their ability to synthesize β-lactamase. In our previous studies, β-lactam/β-lactamase-inhibitor combinations suppressed the growth of several mycobacteria in axenic cultures and ampicillin/sulbactam was bactericidal to Mycobacterium tuberculosis H37Rv in vitro, and to Mycobacterium leprae multiplying in mouse foot-pads. Since...
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