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Increased glycolytic in fibroblast‐like synoviocytes (FLS) of rheumatoid arthritis (RA) not only contributes to early‐stage disease pathogenesis but leads to sustained proliferation of FLS. Given the importance of PKM2 in glycolysis and apoptosis, PKM2 is considered a potential therapeutic and drug discovery target in RA. Total saponins of anemarrhena (TSA), a class of steroid saponins, originated...
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