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Aim
To determine whether there was an explanation as to why the effects of the sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor canagliflozin on amputation risk vary between the CANVAS program and the CREDENCE trial.
Methods
We performed a pooled analysis of patient‐level data from the CANVAS program and the CREDENCE trial. Patient characteristics associated with amputation risk were assessed...
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