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Voxel-based morphometry (VBM) is an automated method allowing identification of anatomical differences in the whole brain without the pre-specification of a region of interests. Spatial normalization is one of the major processes in VBM, which transforms all images to a standard template. A variety of templates were employed in VBM researches in the literature, including the MNI template and study-specific...
Artifacts in magnetic resonance images can make conventional intensity-based segmentation methods very difficult, especially for the spatial intensity non-uniformity induced by the radio frequency (RF) coil. The non-uniformity introduces a slow-varying shading artifact across the images. Many advanced techniques, such as nonparametric, multi-channel methods, cannot solve the problem. In this paper,...
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