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Osteolysis of bone following total hip replacement is a major clinical problem. Examination of the areas surrounding failed implants has indicated an increase in the bone‐resorption‐inducing cytokine, interleukin 1β (IL‐1β). NALP3, a NOD‐like receptor protein located in the cytosol of macrophages, signals the cleavage of pro‐IL‐1β into its mature, secreted form, IL‐1β. Here we showed that titanium...
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