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Transformation of atrioventricular canal endocardium into invasive mesenchyme is a critical antecedent of cardiac septation and valvulogenesis. Previous studies by Pottset al.(Proc. Natl. Acad. Sci. USA88, 1510–1520, 1991) showed that treatment of atrioventricular canal endocardial and myocardial cocultures with TGFβ3 antisense oligodeoxynucleotides blocked mesenchyme formation. Based on this observation,...
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