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Apoptosis of T cells contributes to the immune homeostasis in inflamed organs. A prominent T-cell infiltration is usually seen in human chronic active hepatitis, being associated with liver fibrosis. In order to demonstrate T-cell apoptosis in the hepatic fibrotic tissue, we induced T-cell infiltration in the fibrotic liver of the rat by injecting concanavalin A (Con A), a T-cell mitogen. Lymphocytes...
Abstract. We examined the temporal and spatial expression pattern of transforming growth factor (TGF)-3 RNA during chick embryogenesis from stage6 to stage33 (Hamburger and Hamilton scale) by using in situ hybridization. During cardiogenesis, TGF3 mRNA was first expressed in the premyocardium at stage8 and thereafter it was localized in endocardial cushion tissue and the ventricular myocardium until...
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