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BACKGROUND:The authors report a retrospective analysis of high‐dose ifosfamide, carboplatin, and etoposide (HD‐ICE) for patients with refractory or relapsed neuroblastoma (NB). A major reason for using this regimen was the long time since patients received previous treatment with a platinum compound. The authors also summarized the published experience on ICE in patients with NB.
METHODS:Treatment...
BackgroundWe report a retrospective study of a novel regimen for neuroblastoma (NB) resistant to standard induction or salvage chemotherapy which now routinely includes topotecan.
Patients and MethodsForty‐five patients received carboplatin (500 mg/m2/day, 2×)–irinotecan (50 mg/m2/day, 5×)–temozolomide (250 mg/m2/day, 5×) (HD‐CIT). Only one course was planned. Patients with thrombocytopenia indicative...
BACKGROUND:In what to the authors' knowledge is the first such study for a pediatric cancer, a large database was retrospectively analyzed to assess statistically the likelihood of response to a given salvage therapy in different clinical subsets of patients.
METHODS:Treatment was comprised of high‐dose cyclophosphamide (at a dose of 140 mg/kg), topotecan (at a dose of 8 mg/m2), and vincristine (at...
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