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The δ opioid receptor (DOR) and μ opioid receptor (MOR) are abundantly distributed in the dorsal horn of the spinal cord. Simultaneous activation of each receptor by selective opiate agonists has been shown to result in synergistic analgesic effects. To determine the cellular basis for these functional associations, we examined the electron microscopic immunocytochemical localization of DOR and...
Many of the analgesic effects of opiate drugs and of endogenous opioid ligands, such as Leu 5 -enkephalin (LE) are thought to be mediated in part by μ-opioid receptors (MOR) in the dorsal horn of the spinal cord. To establish the cellular sites for the spinally mediated analgesic effects of MOR activation and potential anatomical substrates for interactions with LE, we examined the ultrastructural...
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