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6-Cyanouridine 5′-phosphate was shown to act as a competitive inhibitor of yeast OMP decarboxylase, with a K i value of 1.1×10 −5 M. Upon binding by the active site of yeast OMP decarboxylase (EC 4.1.1.23), the Raman stretching frequency of the nitrile group of 6-cyanouridine 5′-phosphate decreases from 2240 to 2225cm −1 . Based on the behavior of a model compound, 6-cyano-1,3-dimethyluracil,...
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