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AimsCalpain‐1 is a ubiquitously expressed calcium‐activated intracellular cysteine protease. Altered expression of calpain system proteins has been implicated in cancer progression and response to chemotherapy.
Methods and resultsThe aim of the current study was to confirm previous data that suggested that calpain‐1 expression is associated with relapse‐free survival in trastuzumab‐treated breast...
Aims: The 2005 International Society of Urological Pathology (ISUP) modification of Gleason grading recommended that the highest grade should always be included in the Gleason score (GS) in prostate biopsies. We analysed the impact of this recommendation on reporting of GS 6 versus 7.
Methods and results: Fifteen expert uropathologists reached two‐thirds consensus on 15 prostate biopsies with GS...
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