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Treatment of L1210 cells with prostaglandin A 2 (PGA 2 ) or 9-deoxy-Δ 9,12 -13,14-dihydro PGD 2 (Δ 12 -PGJ 2 ) resulted in significant G2/M arrest and subsequent DNA fragmentation at concentrations that are cytotoxic to the cells. On agarose gel electrophoresis, DNA ladder formation was evident 24 h after the addition of Δ 1 ...
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