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A novel method for desalting protein directly on MALDI-TOF-MS target has been established based on the absorption of peptides with Fe 3 O 4 /TiO 2 nanoparticles. After optimization of experimental conditions, such as the amounts of nanoparticles and washing solutions, 100 fmol myoglobin digested by trypsin in 10 M urea solution could be identified successfully, and reliable...
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