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A new scaffold for combinatorial chemistry has been developed. In a three component reaction using polymer bound acrylic acid, aldehydes and sulfonamides under Baylis-Hillman reaction conditions, substituted 2-methylidene-3-aminoarylsulfonylpropionic acids were synthesised. After cleavage from the solid support, the products were obtained in high purities.
An efficient method for the solid phase synthesis of allylic alcohols via the Baylis-Hillman reaction has been developed. In the presence of DABCO® or 3-quinuclidinol the coupling of resin bound acrylic acid with different aldehydes yields allylic alcohols. Aldehydes with different reactivity were used and gave modest to excellent yields upon simply varying the base or the reaction time. The allylic...
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