Search results for: K. D. Rainsford

Items from 1 to 20 out of 42 results

article

Professor Giampaolo Velo 31.4.1943–17.8.2017

K. D. Rainsford

Inflammopharmacology > 2018 > 26 > 3 > 709-715

article

Yeast RNA extract suppresses human osteoclast resorption in vitro

Melissa D. Cantley, K. D. Rainsford, David R. Haynes

Inflammopharmacology > 2017 > 25 > 5 > 571-576

Aims The aim of this short study was to test the combinations of RNA extracts (both the connective tissue extracts—cartilage and synovia along with yeast extract) found in natural ribonucleotide extract Osteochondrin S (OST) on human osteoclast formation and activity in vitro. Methods In vitro human osteoclasts were treated with the RNA extracts (cartilage, synovia and yeast) at concentrations equivalent...

chapter

Pharmacology and toxicology of COX-2 inhibitors

K. D. Rainsford

Milestones in Drug Therapy > COX-2 Inhibitors > 67-131

The pharmacological premise upon which the prostaglandin G/H synthase II (PGHS-II) or cyclo-oxygenase-2 (COX-2) inhibitors was developed was essentially that founded in the identification of two different genes coding for the cyclo-oxygenases-1 and -2 [1–3]. COX-1 is considered to be a constitutive enzyme that is responsible for “housekeeping” or physiological functions (e.g., some gastrointestinal...

article

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

K. D. Rainsford

Inflammopharmacology > 2016 > 24 > 1 > 65-66

article

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

K. D. Rainsford, Ann L. Parke, Matthew Clifford-Rashotte, W. F. Kean

Inflammopharmacology > 2015 > 23 > 5 > 231-269

Objectives This review examines the pharmacokinetics, modes of action and therapeutic properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and related conditions, as well as osteoarthritis (OA). Key findings Both HCQ and CQ have historically been employed successfully for the treatment...

article

Osteoarthritis of the hand II: chemistry, pharmacokinetics and pharmacodynamics of naproxen, and clinical outcome studies

Garvin J. Leung, K. D. Rainsford, Walter F. Kean

Journal of Pharmacy and Pharmacology > 66 > 3 > 347 - 357

ObjectiveThis article aims to review osteoarthritis of the hand and the role of the non‐steroidal anti‐inflammatory drug (NSAID) naproxen on its management. We discuss the chemical and pharmacological properties of naproxen and the NSAID class, with an emphasis on its mechanism and adverse reactions. In the context of part I of this paper in characterizing hand osteoarthritis (OA), we review clinical...

article

Osteoarthritis of the hand I: aetiology and pathogenesis, risk factors, investigation and diagnosis

Garvin J. Leung, K. D. Rainsford, Walter F. Kean

Journal of Pharmacy and Pharmacology > 66 > 3 > 339 - 346

ObjectiveOsteoarthritis (OA) of the hand can be a debilitating condition that hinders an individual's quality of life. With multiple joints within the hand that are commonly affected OA, an individual's ability to use their hand in everyday movements become more limited. The article aims to review literature on the aetiology and pathogenesis of OA, risk factors, characteristics of hand OA and the...

article

Pharmacology of intra-articular triamcinolone

Justin Scherer, K. D. Rainsford, Colin A. Kean, Walter F. Kean

Inflammopharmacology > 2014 > 22 > 4 > 201-217

Introduction The inflammatory joint diseases of juvenile inflammatory arthritis (JIA), rheumatoid arthritis (RA) and osteoarthritis (OA): and also mild to moderate joint injury, all require a multidisciplinary approach to management. Intra-articular injections of corticosteroids have been shown to be a very beneficial adjunctive treatment in the management of the above disorders. It is, therefore,...

article

Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro

Melissa D. Cantley, K. D. Rainsford, David R. Haynes

Journal of Pharmacy and Pharmacology > 65 > 8 > 1214 - 1222

ObjectivesOsteochondrin S, a natural product derived from connective tissues and yeast, is used to treat osteoarthritis. The aim of this study was to determine the effect of Osteochondrin S on human osteoclast activity in vitro. MethodsOsteoclasts were derived from human peripheral blood mononuclear cells stimulated with macrophage colony‐stimulating factor and receptor activator of nuclear factor...

article

Erratum to: Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

K. D. Rainsford, D. R. Haynes

Inflammopharmacology > 2013 > 21 > 5 > 387-387

article

Comparison of the ability of chondroitin sulfate derived from bovine, fish and pigs to suppress human osteoclast activity in vitro

M. D. Cantley, K. D. Rainsford, D. R. Haynes

Inflammopharmacology > 2013 > 21 > 6 > 407-412

Chondroitin sulfate (CS) compounds are commonly used to manage OA symptoms. Recent literature has indicated that abnormal subchondral bone metabolism may have a role in the pathogenesis of OA. The aim of this study was to access the effects of chondroitin sulfate obtained from bovine, fish and porcine sources on human osteoclast formation and activity in vitro. Human osteoclasts were generated from...

article

The musculoskeletal abnormalities of the Similaun Iceman (“ÖTZI”): clues to chronic pain and possible treatments

Walter F. Kean, Shannon Tocchio, Mary Kean, K. D. Rainsford

Inflammopharmacology > 2013 > 21 > 1 > 11-20

Background and Introduction In 1991, a deceased human male was found frozen in a glacier pool in the Italian Alps in north west Italy, and is now carefully preserved in the South Tyrol Museum of Archaeology, in Bolzano, Italy. The bodily tissues of the 5,300 year old male (colloquially referred to as the Iceman or Ötzi) were well preserved despite damage related to freezing, and glacial movement....

article

Frans P. Nijkamp, Michael J. Parnham (eds): Principles of immunopharmacology, 3rd revised and extended edition

K. D. Rainsford

Inflammopharmacology > 2013 > 21 > 2 > 199-200

article

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

K. D. Rainsford, D. R. Haynes

Inflammopharmacology > 2013 > 21 > 4 > 269-277

This issue of Inflammopharmacology contains papers that have been submitted to commemorate the life and work of Professor Barrie Vernon-Roberts, an outstanding clinical scientist in the field of bone pathology and its pharmacological regulation. This review briefly summarizes his major works and achievements as well as a list of his publications.

article

Ibuprofen: from invention to an OTC therapeutic mainstay

K. D. Rainsford

International Journal of Clinical Practice > 67 > s178 > 9 - 20

The discovery of ibuprofen’s anti‐inflammatory activity by Dr (now Professor) Stewart Adams and colleagues (Boots Pure Chemical Company Ltd, Nottingham, UK) 50 years ago represented a milestone in the development of anti‐inflammatory analgesics. Subsequent clinical studies were the basis for ibuprofen being widely accepted for treating painful conditions at high anti‐rheumatic doses (≤ 2400 mg/d),...

article

Fifty years of ibuprofen: advancing pain and fever management

K. D. Rainsford

International Journal of Clinical Practice > 67 > s178 > 1 - 2

article

Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy

Aleem Adatia, K. D. Rainsford, Walter F. Kean

Journal of Pharmacy and Pharmacology > 64 > 5 > 617 - 625

Objectives Osteoarthritis (OA) of the knee and hip is among the most frequent and debilitating arthritic conditions. Aside from surgical intervention in severe cases, conventional treatment involves relieving painful symptoms with non‐steroidal anti‐inflammatory drugs (NSAIDs), narcotic and non‐narcotic (weak) analgesics and physical therapy. To obtain insight into the extent of pathological changes...

article

Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials

Aleem Adatia, K. D. Rainsford, Walter F. Kean

Journal of Pharmacy and Pharmacology > 64 > 5 > 626 - 636

Objectives We review the pharmacological properties and clinical evidence pertaining to the efficacy of ibuprofen as a first‐line treatment in hip and knee osteoarthritis (OA). In the context of our previous paper's exploration of the aetiology and pathogenesis of OA as a basis for pharmacotherapy, we discuss the pharmacokinetics (PK) and clinical pharmacodynamics (PD) of ibuprofen relevant to OA...

article

Professor Brigitta M. Peskar MD (1942–2012)

K. D. Rainsford

Inflammopharmacology > 2012 > 20 > 6 > 347-348

article

A toxicological investigation of a celery seed extract having anti-inflammatory activity

M. C. Powanda, K. D. Rainsford

Inflammopharmacology > 2011 > 19 > 4 > 227-233

Background and aims An extract of the seed from celery (Apium graviolens) (CSE), and fractions thereof, have been found to possess anti-inflammatory activity, gastro-protective activity, and anti-Helicobacter pylori activity. In view of the potential for employing these extracts for therapeutic use, toxicological investigations were undertaken with an alcoholic extract (A-CSE) which has previously...

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Search results for: K. D. Rainsford

Professor Giampaolo Velo 31.4.1943–17.8.2017

Yeast RNA extract suppresses human osteoclast resorption in vitro

Pharmacology and toxicology of COX-2 inhibitors

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

Osteoarthritis of the hand II: chemistry, pharmacokinetics and pharmacodynamics of naproxen, and clinical outcome studies

Osteoarthritis of the hand I: aetiology and pathogenesis, risk factors, investigation and diagnosis

Pharmacology of intra-articular triamcinolone

Effects of Osteochondrin S and select connective tissue ribonucleinate components on human osteoclasts in vitro

Erratum to: Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

Comparison of the ability of chondroitin sulfate derived from bovine, fish and pigs to suppress human osteoclast activity in vitro

The musculoskeletal abnormalities of the Similaun Iceman (“ÖTZI”): clues to chronic pain and possible treatments

Frans P. Nijkamp, Michael J. Parnham (eds): Principles of immunopharmacology, 3rd revised and extended edition

Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA

Ibuprofen: from invention to an OTC therapeutic mainstay

Fifty years of ibuprofen: advancing pain and fever management

Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy

Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials

Professor Brigitta M. Peskar MD (1942–2012)

A toxicological investigation of a celery seed extract having anti-inflammatory activity

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