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Background
Encouraging responses to histone deacetylase inhibitors have been reported for hematologic malignancies. Here, we report effects of panobinostat and 5‐azacytidine on the proliferation of juvenile myelomonocytic leukemia (JMML) CD34+ cells.
Procedure
We previously reported that stimulation of JMML CD34+ cells with stem cell factor and thrombopoietin on irradiated murine AGM‐S3 cells led...
Mechanisms of relapse of acute lymphoblastic leukemia (ALL) after human leukocyte antigen (HLA) class II mismatched hematopoietic stem cell transplantation (HSCT) remain unclear. We report two children with relapsed ALL after HSCT from related donors with HLA‐DRB1 and ‐DQB1 mismatches in the graft versus host direction. One lost HLA‐DRB1, DQB1, and DPB1 alleles, and the other lost one HLA haplotype...
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