Search results for: Swen Hesse

Items from 1 to 20 out of 62 results

article

Noradrenergic control of neurobehavior in human binge‐eating disorder and obesity (NOBEAD): A smartphone‐supported behavioral emotion regulation intervention study protocol integrating molecular brain imaging

Swen Hesse, Michael Rullmann, Franziska Zientek, Danielle Schewe, more

International Journal of Eating Disorders > 57 > 1 > 206 - 220

Objective The neurobehavioral underpinnings of binge‐eating disorder (BED), co‐occurring with obesity (OB), are largely unknown. This research project conceptualizes BED as a disorder with dysfunctional emotion regulation (ER) linked with changes in central noradrenaline (NA) transmission and NA‐modulated neuronal networks. Methods We expect abnormalities in NA activity in both BED and OB, but...

article

JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps

Juergen Dukart, Stefan Holiga, Michael Rullmann, Rupert Lanzenberger, more

Human Brain Mapping > 42 > 3 > 555 - 566

Recent studies have shown that drug‐induced spatial alteration patterns in resting state functional activity as measured using magnetic resonance imaging (rsfMRI) are associated with the distribution of specific receptor systems targeted by respective compounds. Based on this approach, we introduce a toolbox (JuSpace) allowing for cross‐modal correlation of MRI‐based measures with nuclear imaging...

article

Current radiotracers to image neurodegenerative diseases

Solveig Tiepolt, Marianne Patt, Gayane Aghakhanyan, Philipp M. Meyer, more

EJNMMI Radiopharmacy and Chemistry > 2019 > 4 > 1 > 1-23

The term of neurodegenerative diseases covers a heterogeneous group of disorders that are distinguished by progressive degeneration of the structure and function of the nervous system such as dementias, movement disorders, motor neuron disorders, as well as some prion disorders. In recent years, a paradigm shift started for the diagnosis of neurodegenerative diseases, for which successively clinical...

article

Noradrenaline transporter availability on [¹¹C]MRB PET predicts weight loss success in highly obese adults

Franziska J. Vettermann, Michael Rullmann, Georg A. Becker, Julia Luthardt, more

European Journal of Nuclear Medicine and Molecular Imaging > 2018 > 45 > 9 > 1618-1625

Purpose Although the mechanisms by which the central noradrenaline (NA) system influences appetite and controls energy balance are quite well understood, its relationship to changes in body weight remains largely unknown. The main goal of this study was to further clarify whether the brain NA system is a stable trait or whether it can be altered by dietary intervention. Methods We aimed to compare...

article

The association between in vivo central noradrenaline transporter availability and trait impulsivity

Swen Hesse, Ulrich Müller, Michael Rullmann, Julia Luthardt, more

Psychiatry Research: Neuroimaging > 2017 > 267 > C > 9-14

The brain noradrenaline (NA) system, particularly NA transporters (NAT), are thought to play an important role in modulating impulsive behavior. Impaired impulsivity is implicated in a variety of neuropsychiatric conditions; however, an in vivo link between central NAT availability and human impulsivity has not been shown. Using positron emission tomography (PET) and S,S-[¹¹C]O-methylreboxetine (MRB),...

article

Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity

Christian Schinke, Swen Hesse, Muriel Stoppe, Klara Meyer, more

Psychoneuroendocrinology > 2017 > 78 > C > 39-47

Increased activities of the arginine-vasopressin (AVP) system and the hypothalamic-pituitary-adrenal (HPA) axis were shown to be associated with human obesity, but relationships between these systems in obesity remain unclear.To assess HPA axis responsiveness and its relation to serum concentrations of the AVP-surrogate copeptin in subjects with obesity (OB) in comparison to non-obesity controls (NOC)...

article

Feasibility of in vivo ¹⁸F-florbetaben PET/MR imaging of human carotid amyloid-β

Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, more

European Journal of Nuclear Medicine and Molecular Imaging > 2017 > 44 > 7 > 1119-1128

Purpose Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. ¹⁸F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer’s disease (AD). We sought to determine whether specific uptake of ¹⁸F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is associated with...

article

Test–retest measurements of dopamine D₁-type receptors using simultaneous PET/MRI imaging

Simon Kaller, Michael Rullmann, Marianne Patt, Georg-Alexander Becker, more

European Journal of Nuclear Medicine and Molecular Imaging > 2017 > 44 > 6 > 1025-1032

Purpose The role of dopamine D₁-type receptor (D₁R)-expressing neurons in the regulation of motivated behavior and reward prediction has not yet been fully established. As a prerequisite for future research assessing D₁-mediated neuronal network regulation using simultaneous PET/MRI and D₁R-selective [¹¹C]SCH23390, this study investigated the stability of central D₁R measurements between two independent...

article

Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

Mohammed K. Hankir, Florian Seyfried, Constantin A. Hintschich, Thi-Ai Diep, more

Cell Metabolism > 2017 > 25 > 2 > 335-344

Bariatric surgery remains the single most effective long-term treatment modality for morbid obesity, achieved mainly by lowering caloric intake through as yet ill-defined mechanisms. Here we show in rats that Roux-en-Y gastric bypass (RYGB)-like rerouting of ingested fat mobilizes lower small intestine production of the fat-satiety molecule oleoylethanolamide (OEA). This was associated with vagus...

article

[¹²³I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

Livia Tossici-Bolt, John C. Dickson, Terez Sera, Jan Booij, more

EJNMMI Physics > 2017 > 4 > 1 > 1-16

Background [¹²³I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-specific reference values for the [¹²³I]FP-CIT specific binding ratio (SBR) under optimised protocols for image acquisition and processing. Simpler reconstruction methods, however,...

article

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [¹²³I]FP-CIT SPECT imaging

John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, more

EJNMMI Research > 2017 > 7 > 1 > 1-11

Background The use of a normal database for [¹²³I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretation. The aim of this study was to assess whether the use of different tomographic reconstructions affects the performance of a normal [¹²³I]FP-CIT SPECT database and also whether...

article

Central noradrenaline transporter availability in highly obese, non-depressed individuals

Swen Hesse, Georg-Alexander Becker, Michael Rullmann, Anke Bresch, more

European Journal of Nuclear Medicine and Molecular Imaging > 2017 > 44 > 6 > 1056-1064

Purpose The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. Methods We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity...

article

Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18 F]FDG PET: the autoimmune encephalitis

Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, more

European Journal of Nuclear Medicine and Molecular Imaging > 2017 > 44 > 3 > 559-560

The online version of the original article can be found at http://dx.doi.org/10.1007/s00259-016-3589-9 .

article

The need of standardization and of large clinical studies in an emerging indication of [¹⁸F]FDG PET: the autoimmune encephalitis

Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, more

European Journal of Nuclear Medicine and Molecular Imaging > 2017 > 44 > 3 > 353-357

An erratum to this article is available at http://dx.doi.org/10.1007/s00259-016-3598-8 .

article

The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [11C]DASB positron emission tomography study

Philipp Hinderberger, Michael Rullmann, Mandy Drabe, Julia Luthardt, more

Neuropharmacology > 2016 > 110 > PA > 530-536

Serotonin (5-HT) and its neurotrophic support system, specifically brain-derived neurotrophic factor (BDNF), are thought to modulate energy homeostasis and susceptibility to obesity. Moreover, a polymorphism (5-HTTLPR) in the serotonin reuptake transporter (5-HTT) gene impairs its transcription, thereby altering serotonergic tone and potentially contributing to such susceptibility. This study aims...

article

Effortful control as a dimension of temperament is negatively associated with prefrontal serotonin transporter availability in obese and non‐obese individuals

Franziska Zientek, Karsten Winter, Astrid Müller, Michael Rullmann, more

European Journal of Neuroscience > 44 > 7 > 2460 - 2466

There is evidence that temperamental factors are associated with obesity; however, the biological mechanism of such association remains elusive. We aimed to investigate a possible association between serotonin transmission and regulative temperament in obese and non‐obese individuals by using positron emission tomography (PET) imaging of serotonin transporters (SERT) and the Adult Temperament Questionnaire...

article

Role of 18F-FDG-PET imaging in the diagnosis of autoimmune encephalitis

Silvia Morbelli, Mehdi Djekidel, Swen Hesse, Marco Pagani, more

The Lancet Neurology > 2016 > 15 > 10 > 1009-1010

article

Feasibility and acceptance of simultaneous amyloid PET/MRI

Lisa Schütz, Donald Lobsien, Dominik Fritzsch, Solveig Tiepolt, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 12 > 2236-2243

Purpose Established Alzheimer’s disease (AD) biomarker concepts classify into amyloid pathology and neuronal injury biomarkers, while recent alternative concepts classify into diagnostic and progression AD biomarkers. However, combined amyloid positron emission tomography/magnetic resonance imaging (PET/MRI) offers the chance to obtain both biomarker category read-outs within one imaging session,...

article

In-vivo serotonin transporter availability and somatization in healthy subjects

Anke Bresch, Michael Rullmann, Julia Luthardt, Katrin Arelin, more

Personality and Individual Differences > 2016 > 94 > C > 354-359

Dysregulation of the central serotonergic system is implicated in somatization, which can lead to manifest mental disease. However, neuroimaging studies on serotonin transporter (SERT) availability and somatoform symptoms as assessed by the Symptom Checklist 90 Revised (SCL-90-R) are sparse and reveal inconsistent results. The aim of this study was to explore for the first time the relationship between...

article

Evaluation of software tools for automated identification of neuroanatomical structures in quantitative β-amyloid PET imaging to diagnose Alzheimer’s disease

Tobias Tuszynski, Michael Rullmann, Julia Luthardt, Daniel Butzke, more

European Journal of Nuclear Medicine and Molecular Imaging > 2016 > 43 > 6 > 1077-1087

Introduction For regional quantification of nuclear brain imaging data, defining volumes of interest (VOIs) by hand is still the gold standard. As this procedure is time-consuming and operator-dependent, a variety of software tools for automated identification of neuroanatomical structures were developed. As the quality and performance of those tools are poorly investigated so far in analyzing amyloid...

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INFONA - science communication portal

Search results for: Swen Hesse

Noradrenergic control of neurobehavior in human binge‐eating disorder and obesity (NOBEAD): A smartphone‐supported behavioral emotion regulation intervention study protocol integrating molecular brain imaging

JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps

Current radiotracers to image neurodegenerative diseases

Noradrenaline transporter availability on [¹¹C]MRB PET predicts weight loss success in highly obese adults

The association between in vivo central noradrenaline transporter availability and trait impulsivity

Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity

Feasibility of in vivo ¹⁸F-florbetaben PET/MR imaging of human carotid amyloid-β

Test–retest measurements of dopamine D₁-type receptors using simultaneous PET/MRI imaging

Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

[¹²³I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [¹²³I]FP-CIT SPECT imaging

Central noradrenaline transporter availability in highly obese, non-depressed individuals

Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18 F]FDG PET: the autoimmune encephalitis

The need of standardization and of large clinical studies in an emerging indication of [¹⁸F]FDG PET: the autoimmune encephalitis

The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [11C]DASB positron emission tomography study

Effortful control as a dimension of temperament is negatively associated with prefrontal serotonin transporter availability in obese and non‐obese individuals

Role of 18F-FDG-PET imaging in the diagnosis of autoimmune encephalitis

Feasibility and acceptance of simultaneous amyloid PET/MRI

In-vivo serotonin transporter availability and somatization in healthy subjects

Evaluation of software tools for automated identification of neuroanatomical structures in quantitative β-amyloid PET imaging to diagnose Alzheimer’s disease

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