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We investigated whether transforming growth factor-β (TGF-β) stimulates the induction of heat shock protein (HSP) 27 and HSP70 in osteoblast-like MC3T3-E1 cells and the mechanism underlying the induction. TGF-β increased the level of HSP27 but had no effect on the HSP70 level. TGF-β stimulated the accumulation of HSP27 dose-dependently, and induced an increase in the level of mRNA for HSP27. TGF-β...
We investigated the effects of transforming growth factor-β (TGF-β) on biological behavior of a weakly malignant rat mammary carcinoma ER-1 cell line. TGF-β enhanced the tumorigenic and metastatic capacity of ER-1 cells and their in vitro invasiveness to rat mesothelial and endothelial cell. Further cell biological analysis indicated that the increased invasive and metastatic capacity of ER-1 cells...
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