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Background
Adipose‐derived stem cells have been considered as a promising therapy for erectile dysfunction. However, the therapeutic efficacy of adipose‐derived stem cell‐based therapy requires improvement.
Objective
To determine whether the inhibition of phosphodiesterase type 5 in adipose‐derived stem cells would improve stem cell therapy for rats with diabetes‐induced erectile dysfunction.
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Excessive production of reactive oxygen species (ROS) by an overactive nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system in penile tissue is an important mechanism of erectile dysfunction (ED). S‐allyl cysteine (SAC), a bioactive component derived from garlic, was recently reported to exert versatile antioxidant properties. We hypothesized that SAC would be able to resolve diabetes‐related...
Many factors, such as nitric oxide synthase, androgen and growth factors, can regulate the tone of corpus cavernosum (CC) smooth muscle with an age‐related tendency. It has been shown that the active metabolites of kallikreins–kinins system (KKS), including bradykinin, Lys‐BK and Met‐Lys‐BK, can also relax the CC smooth muscle significantly in vitro. Our aim was to evaluate the specific association...
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