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Apelin peptides are now known to be endogenous ligands at the orphan G-protein coupled receptor, APJ. Apelin and its receptor have been found in the brainstem and shown to have a role in haemodynamic homeostasis when injected intravenously. The physiological role of this peptide and its receptor centrally are yet to be elucidated. In this study, urethane anaesthetised, paralysed and ventilated male...
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