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NKT cells are CD1d-restricted, glycolipid antigen-reactive, immunoregulatory T lymphocytes that can serve as a bridge between the innate and adaptive immunities. NKT cells have a wide range of therapeutic application in autoimmunity, transplant biology, infectious disease, cancer, and vaccinology. Rather than triggering “danger signal” and eliciting an innate immune response, αGalCer-based NKT-cell...
Chemical and enzymatic methods to synthesis of 2-acetamido-2-deoxy-d-mannose-6-phosphate (ManNAc-6-P) have been investigated. A new preparative method has been developed although some established procedures were tried. In this new method, a 6-O-acetyl or 4,6-di-O-acetyl group of the per-O-acetylated 2-acetamido-2-deoxy-d-mannose (ManNAc) were regioselectively removed with an esterase from the yellow...
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