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Microcapsules have been prepared via a complex coacervation reaction from polyanion and polycation mixtures. Multicomponent blends of synthetic, semi-synthetic and naturally occurring macromolecules have been evaluated with a particular interest in the preparation of immunoisolation barriers for pancreatic islets. A screening has resulted in thirty three polymeric systems which have been compared...
Seventy five synthetic, semi-synthetic, natural and biological water soluble polymers have been evaluated as potential biomaterials for cell and islet immunoisolation. Measurements have included the cytotoxicity of polyanion and polycation solutions towards insulinoma cells as well as the type of complex coacervate interaction produced. These results have been coupled with metrics delineating the...
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